段新方（homepage）
段新方 博士，教授，博士生导师
北京师范大学化学学院 有机化学研究所
北京市新街口外大街19号
邮编 100875
E-mail: xinfangduan@vip.163.com
Tel：010-58805177(Lab)
Fax: 01058802075
讲授课程
本科生：基础有机化学（I）
研究生: 高等有机化学
研究兴趣（招生方向：过渡金属催化与有机合成）
有机合成化学：杂环化合物的合成，天然产物的全合成，药物的新法合成；
金属有机化学：过渡金属催化偶联反应，有机金属试剂的制备及反应。
承担课题
国家自然科学基金项目：交叉型McMurry 反应的研究与应用 （2007.1―2009.12）
国家自然科学基金项目：含氮杂环的氮氧化物，季铵盐及路易斯酸盐直接偶联和羰基化反应的研究与应用 （2011.1―2013.12）
教育部博士点基金：含氮杂环N-氧化物与含氮杂环盐 C-H 活化直接偶联反应的研究与应用 （2011.1―2013.12）
国家自然科学基金项目：铁钴催化的有机钛试剂协同型偶联反应的研究（2013.1―2013.12）
国家自然科学基金项目：铁钴催化的有机钛试剂协同型偶联反应的研究（2014.1―2017.12）
国家自然科学基金项目：新型ate-络合物的设计、合成与反应研究（2016.1―2019.12）
国家自然科学基金项目：钛族金属与廉价过渡金属的双金属协同研究（2022.1―2025.12）
横向项目：莫沙必利合成工艺的改进；脂肪族溴代物制备工艺的改进；
新型联吡啶类化合物的设计与合成
代表性论文
1. Xia, D.; Duan, X. F.* Tandem vinyl radical Minisci-type annulation on pyridines: one pot expeditious access to azaindenones, Chem. Commun., 2021, 57,13570.
2.
Xia, D.;
Duan, X. F.* Alkylative Dearomatization by Using an
Unactivated Aryl Nitro Group as a Leaving Group: Access to Diversified Alkylated Spiro[5.5]trienones, Org. Lett. 2021,
23, 2548.
3. Xia, D.; Duan, X. F.* Iron-Catalyzed Dearomatization of Biaryl
Ynones with Aldehydes via Double C−H Functionalization in Eco-Benign Solvents:
Highly Atom-Economical Synthesis of Acylated Spiro[5.5]trienones, J. Org.
Chem. 2021, 86, 15263.
4.
Wei, Y. M.; Ma, X. D.; Wang, L.; Duan, X. F.* Iron-catalyzed
stereospecific arylation of enol tosylates using Grignard reagents, Chem. Commun., 2020, 56, 1101.
5.
Duan, X. F.* Iron catalyzed
stereoselective alkene synthesis: a sustainable pathway Chem. Commun., 2020, 56, 14937 (Feature Article).
6.
Wei, Y. M.; Wang, M. F.; Duan, X. F.* Is Fe-catalyzed ortho C−H Arylation of Benzamides Sensitive
to Steric Hindrance and Directing Group? Org. Lett. 2019, 21,
6471.
7. Wang, L.; Wei, Y.
M.; Zhao, Y.; Duan, X. F.* Unified Protocol for Fe-Based Catalyzed Biaryl Cross-Couplings
between Various Aryl Electrophiles and Aryl Grignard Reagents. J. Org. Chem.
2019, 84, 5176.
8.
Xu, L. C; Liu, K. M.; Duan, X. F.* Iron-Catalyzed Room Temperature Cross-Couplings of
Bromophenols with Aryl Grignard Reagents, Adv. Synth. Catal. 2019, 361, 5421
(Highlighted by Org. Process Res. Dev.).
9.
Zhang, R.; Zhao, Y.; Liu, K. M.; Duan, X. F.* Phenolate Enabled General and Selective Fe/Ti Cocatalyzed
Biaryl Cross-Couplings between Aryl Halides and Aryl Grignard Reagents, Org.
Lett. 2018, 20, 7942 (Highlighted by Synfacts and Org. Process Res. Dev.)
10.
Wei, J. Liu, K. M.; Duan, X. F.*
Cobalt-Catalyzed Biaryl Couplings via C−F Bond Activation in the Absence of
Phosphine or NHC Ligands, J. Org. Chem. 2017, 82, 1291 (Cover Art,
Highlighted by Synfacts and Org. Process Res.
Dev.).
11.
Liu, K. M.; Zhang, R.; Duan, X. F.* Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding
the ortho-selectivity via the oxidative assembly of carboxylate and aryl
titanate reagents using oxygen, Org. Biomol.
Chem., 2016, 14, 1593.
12.
Liu, K. M.; Liao, L. Y.; Duan, X. F.* Iron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using
oxygen as an oxidant, Chem. Commun., 2015, 51, 1124 (Highlighted by
Synfacts).
13.
Liu, K. M.; Wei, J.; Duan, X. F.* Iron-catalyzed oxidative biaryl cross-couplings via mixed diaryl titanates: significant
influence of the order of combining aryl Grignard reagents with titanate, Chem. Commun., 2015, 51, 4655.
14.
Liao, L. Y.; Liu, K. M.; Duan, X. F.* Unified Protocol for
Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as
an Oxidant, J. Org. Chem. 2015, 80, 9856 (Feature Article).
15.
Liao, L. Y.; Kong,
X.-R.; Duan, X. F.* Reductive Couplings of 2‑Halopyridines without External Ligand: Phosphine-Free
Nickel-Catalyzed Synthesis of Symmetrical and Unsymmetrical 2,2′-Bipyridines, J. Org. Chem. 2014, 79, 777.
16. Zhang, S.; Liao, L. Y.; Zhang, F.; Duan, X. F.*
Arylation, Alkenylation, and Alkylation of 2‑Halopyridine N‑Oxides with Grignard Reagents: A Solution to the Problem
of C2/C6 Regioselective Functionalization of Pyridine Derivatives, J. Org.
Chem. 2013, 78, 2720 (Highlighted by Synfacts).
17. Zeng, J.; Liu, M. K.; Duan, X. F.* Selective Co/Ti
Cooperatively Catalyzed Biaryl Couplings of Aryl Halides with Aryl Metal
Reagents, Org. Lett. 2013, 15, 5342 (Highlighted by Synfacts).
18. Liu, K. M.; Zhang, F.; Duan, X.
F.* 1, 2-Addition of Alkyl Grignard Reagents to the Nitro Group: Simple Access
to 2-[Alkyl(hydroxy)amino]pyridine N-Oxides and 2-Alkylaminopyridine N-Oxides,
Eur. J. Org. Chem. 2013, 6152.
19. Zhang, F.; Zhang, S.; Duan, X. F.* Substitution of the
Nitro Group with Grignard Reagents: Facile Arylation and Alkenylation of
Pyridine N‑Oxides, Org. Lett.
2012, 14, 5618.
20.
Liao, L. Y.; Shen,
G.; Zhang, X.; Duan, X. F.* A Practicable Environmentally Benign One-pot Synthesis
of 2-Arylbenzofurans at Room Temperature, Green
Chem. 2012, 14, 695.
21.
Zhang, F.; Duan, X.
F.* Facile One-Pot Direct Arylation and Alkylation of Nitropyridine N-Oxides
with Grignard Reagents, Org. Lett. 2011, 13, 6102. (Highlighted by
Synfacts).
22.
Zhang, Z. B.;
Lu, Y. Q.; Duan, X. F.* An Efficient
Direct Asymmetric Synthesis of 3-Substituted Phthalides, Synthesis, 2011, 3435.
23.
Duan, X. F.*;
Sheng, G.; Zhang, Z. B. A Concise Synthesis of Natural
Benzofuran Neolignans and Analogues,
Synthesis, 2010, 2547.
24.
Duan, X. F.*; Feng,
J. X.; Zhang, Z. B. A Convenient Two-Step Synthesis of
2-Arylbenzofurans, Synthesis, 2010, 515.
25.
Duan, X. F.*;
Sheng, G.; Zhang, Z. B. Total Synthesis of Ailanthoidol, Egonol and Some Related Analogues,
Synthesis, 2010, 1181.
26.
Duan, X. F.*; Ma,
Z. Q.; Zhang, F.; Zhang, Z. B.
Magnesiation of Pyridine N-Oxides via Iodine or Bromine-Magnesium Exchange: A Useful
Tool for Functionalizing Pyridine N-Oxides. J. Org. Chem. 2009, 74, 939.
27.
Duan, X. F.*; Feng,
J. X.; Zi, G. F.; Zhang, Z. B. A Convenient Synthesis of Unsymmetrical Pinacols
through Selective Cross-Couplings between Structurally- Similar Aromatic
Aldehydes Mediated by Low Valent Titanium, Synthesis,
2009, 277.
28.
Duan, X. F.*; Zeng, J.; Zhang, Z. B.; Zi, G. F. Facile Two-step
Synthesis of 2-Arylbenzofurans Based on the Selective Cross McMurry Couplings,
J. Org. Chem., 2007, 72, 10283.
29.
Duan, X. F.*; Zeng, J.; Lü, J. W.; Zhang, Z. B.; A Facile
Synthesis of Tetraarylethenes via Cross McMurry Coupling between Diaryl
Ketones, Synthesis, 2007, 713.
30.
Duan, X. F.*; Zeng, J.; Lü, J. W.; Zhang, Z. B. Insights
into the General and Efficient Cross McMurry Reactions between Ketones J.
Org. Chem., 2006, 71, 9873.
授权专利：
1. 一种一锅法合成苯并呋喃衍生物的方法, CN102584512
2.
一种联吡啶衍生物或类似物的合成方法，CN103664769
3.
一种铁催化的联芳烃及其衍生物的合成方法, CN110372544B
4.
一种一步法合成二氟尼柳及其衍生物的方法, CN110372493B
已毕业研究生 曾竟，李襄宏，吕佳蔚，马子倩，冯建霞，沈刚，吴玉花，卢永勤（合作），张芳，段晓锋，孔兴蕊，张嵩，刘昆明，廖连燕，魏娟, 张锐，汪梦飞，赵岩，王蕾，夏冬
在读研究生 徐立晨（博士），马姗姗（博士），魏奕鸣（博士）, 马晓娣(博士)，赵金龙（硕士），赵国华（硕士），马芳媛（硕士），焦苗苗（硕士）